Continuous matching zipper-like

Target123456789
│││││││││
Partner✓✓✓✓✓✓✓✓✓

VIPR matching two paired, one displaced

DNA123456789
││↷││↷││↷
Guide RNANN—NN—NN—
one Vipr copyone Vipr copyone Vipr copy
GGY tucked awayGGY tucked awayGGY tucked away

The variable NN bases carry the address. The repeating protein scaffold preserves each gap and grips the nucleic-acid strands around it.

paired positionunpaired DNA base